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Amoxil (Amoxicillin)

Brand name : Amoxil, Biomox , Siamox

Generic Name : Amoxicillin

Medicine Categories :

Antibiotics,Quindone,Cephalosporins,Macrolides: Penicillins

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Category B : Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women, or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the first trimester (and there is no evidence of a risk in later trimesters).

What is it used for?

- Abdominal infections (peritonitis)
- Bacterial infection of the heart valves and the lining surrounding the heart (bacterial endocarditis)
- Bacterial infection of the middle ear (otitis media)

- Bronchitis
- Dental abscess (as addition to surgical management)
- Eradicating bacteria in the gut (Helicobacteria pylori) that cause ulcers (in combination with other medicines)

- Gonorrhoea
- Gynaecological infections, including those following childbirth or abortion
- Infection of the blood (septicaemia or blood poisoning)

- Infections of the organs associated with breathing, including nasal passages, sinuses, windpipe and lungs (respiratory tract)
- Infections of the urinary tract
- Pneumonia

- Preventing infection of the heart (bacterial endocarditis) during medical or dental procedures in people with heart valve defects or artificial heart valves
- Skin or soft tissue infections
- Typhoid and paratyphoid fever

How does it work?

This medicine contains the active ingredient amoxicillin (sometimes spelt amoxycillin), which belongs to a group of antibiotics called penicillins. It is used to treat infections caused by bacteria.

Amoxicillin works by interfering with the ability of bacteria to form cell walls. The cell walls of bacteria are vital for their survival. They keep unwanted substances from entering their cells and stop the contents of their cells from leaking out. Amoxicillin impairs the bonds that hold the bacterial cell wall together. This allows holes to appear in the cell walls and kills the bacteria.

Amoxicillin is a broad-spectrum antibiotic that kills a wide variety of bacteria that cause a wide variety of commonly-occuring infections. Amoxicillin may be used to treat infections of the upper or lower airways, skin or soft tissue, or ears. It may also be used to treat urine infections, certain sexually-transmitted infections, dental infections, and infections affecting the blood or internal organs.

To make sure the bacteria causing an infection are susceptible to amoxicillin your doctor may take a tissue sample, for example a swab from the throat or skin, or a urine or blood sample.

How should Amoxil (Amoxicillin) be used?

Amoxil comes as a capsule, chewable tablet, liquid, and pediatric drop to take by mouth. It is usually taken every 8 hours (three times a day). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Amoxil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Shake the liquid and pediatric drops well before each use to mix Amoxil evenly. Use the bottle dropper to measure the dose of pediatric drops. The pediatric drops and liquid may be placed on a child's tongue or added to formula, milk, fruit juice, water, ginger ale, or other cold liquid and taken immediately.

The tablets should be crushed or chewed thoroughly before they are swallowed. The capsules should be swallowed whole and taken with a full glass of water.
Continue to take Amoxil even if you feel well.

Do not stop taking Amoxil without talking to your doctor.


- This medicine may interfere with urine tests for glucose, causing the test to give a "false positive" result. That is, the test may say that glucose is present in the urine even if it is not.

- Unless your doctor tells you otherwise, it is important that you finish the prescribed course of this antibiotic medicine, even if you feel better or it seems the infection has cleared up. Stopping the course early increases the chance that the infection will come back and that the bacteria will grow resistant to the antibiotic.

- Broad-spectrum antibiotics can sometimes cause diarrhoea. If you experience diarrhoea that becomes severe or persistent or contains blood or mucus, either during or after taking this medicine, you should consult your doctor immediately.

Use with caution in

- Chronic lymphocytic leukaemia
- Decreased kidney function
- Glandular fever

Not to be used in

- Allergy to penicillin or cephalosporin type antibiotics

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby.Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

- There are no known harmful effects when this medicine is used during pregnancy.
- The medicine passes into the breast milk, but at normal doses it is unlikely to harm the baby. Discuss with your doctor.

Label Warning

Take at regular intervals. Complete the prescribed course unless otherwise directed.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

- Rash
- Itching (pruritus)
- Diarrhoea
- Vomiting
- Nausea
- Blood disorders
- Allergic reaction to active ingredient
- Dizziness
- Overgrowth of the yeast Candida, which may cause infection such as thrush
- Inflammation of the large intestine (colitis)

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

There may be an increased risk of experiencing a rash as a side effect of this medicine if you are also taking allopurinol.

Amoxicillin may decrease the removal of methotrexate from the body, increasing the risk of side effects. If you are taking methotrexate you should be well monitored by your doctor while you are taking a course of this antibiotic.

Probenecid increases the blood level of amoxicillin, and poeple taking probenecid may be prescribed a lower dose of amoxicillin.

Amoxicillin may rarely alter the anti-blood-clotting effects of anticoagulant medicines such as warfarin. Your doctor may wish to monitor your blood clotting time while you are taking both medicines.

If you are taking a combined oral contraceptive pill there may be a very low risk that this antibiotic may make it less effective at preventing pregnancy. Although the risk of this is very low, the personal and ethical consequences of an unwanted pregnancy can be very serious. For this reason the Family Planning Association recommends that women taking combined oral contraceptives should use an extra method of contraception (eg condoms) while taking a short course of broad-spectrum antibiotic, and for seven days after finishing the course. If the seven days run beyond the end of a pill packet, a new packet should be started without a break (in the case of ED pills the inactive tablets should be omitted).

It is especially important to check with your doctor before combining Amoxicillin with the following:

- Chloramphenicol (Chloromycetin)
- Erythromycin (E.E.S., PCE, others)
- Oral contraceptives
- Probenecid (Benemid)
- Tetracycline (Achromycin V, others)

Recommended dosage

Oral 1 cap or 1 tsp tid. Inj 500-1000 mg IM 8 hrly or slow IV.
Dosages will be determined by the type of infection being treated.


Ear, Nose, Throat, Skin, Genital, and Urinary Tract Infections
The usual dosage is 250 milligrams, taken every 8 hours.

Infections of the Lower Respiratory Tract
The usual dosage is 500 milligrams, taken every 8 hours.

The usual dosage is 3 grams in a single oral dose.

Gonococcal Infections Such as Acute, Uncomplicated Anogenital and Urethral Infections
3 grams as a single oral dose.

1 gram of Amoxicillin in combination with 500 milligrams of Biaxin and 30 milligrams of Prevacid taken every 12 hours for 14 days.
Alternatively, 1 gram of Amoxil can be taken with 30 milligrams of Prevacid every 8 hours for 14 days.


Children weighing 44 pounds and over should follow the recommended adult dose schedule.
Children weighing under 44 pounds will have their dosage determined by their weight.

Dosage of Pediatric Drops :

Use the dropper provided with the medication to measure all doses.
All Infections Except Those of the Lower Respiratory Tract

Under 13 pounds:
0.75 milliliter every 8 hours.

13 to 15 pounds:
1 milliliter every 8 hours.

16 to 18 pounds:
1.25 milliliters every 8 hours.

Infections of the Lower Respiratory Tract

Under 13 pounds:
1.25 milliliters every 8 hours.

13 to 15 pounds:
1.75 milliliters every 8 hours.

16 to 18 pounds:
2.25 milliliters every 8 hours.

Children weighing more than 18 pounds should take the oral liquid. The required amount of suspension should be placed directly on the child's tongue for swallowing. It can also be added to formula, milk, fruit juice, water, ginger ale, or cold drinks. The preparation should be taken immediately. To be certain the child is getting the full dose of medication, make sure he or she drinks the entire preparation.


Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.
Symptoms of Amoxil overdose may include:
Diarrhea, nausea, stomach cramps, vomiting

When you miss a dose

Take it as soon as you remember. If it is almost time for the next dose, and you take 2 doses a day, take the one you missed and the next dose 5 to 6 hours later. If you take 3 or more doses a day, take the one you missed and the next dose 2 to 4 hours later. Then go back to your regular schedule.


Amoxicillin suspension and pediatric drops should be stored in a tightly closed bottle. Discard any unused medication after 14 days. Refrigeration is preferable.

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