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Elavil , Tryptanol (Amitriptyline)

Brand name : Elavil , Tryptanol

Generic Name : Amitriptyline

Manufacturer : Merck Sharp & Dohme

Drug Category : Antidepressants , Anti-migraine ,Antibulimic ,Antienuretic ,Antineuralgic

Class: tricyclic antidepressant

FDA Pregnant Category :

Category C : Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women, or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.

Available in VrDrug.com store :

Brand and Generic : 10 ,25 and 50 mg.

Pregnancy and Breast feeding :

Drug may pass into milk. Avoid drug or discontinue nursing until you finish medicine.

General Information :

Amitriptyline is prescribed for the relief of symptoms of mental depression. It is a member of the group of drugs called tricyclic antidepressants.


It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance.


Amitriptyline is also sometimes used to treat eating disorders (bulimia)and post-herpetic neuralgia (stabbing pains ,the burning, or aches that may last for months or years after a shingles infection). to control chronic pain, to prevent migraine headaches, to decrease bedwetting in children, and to treat a pathological weeping and laughing syndrome associated with multiple sclerosis.

Off-Label (Newly Discovered uses) :

Chronic fatigue syndrome, chronic nausea and vomiting, chronic neuropathic pain, diabetic neuropathy, dyspepsia, fibromyalgia, interstitial cystitis, irritable bowel syndrome, migraine prevention, multiple sclerosis, panic disorder, post-herpetic neuralgia, post-traumatic stress disorder, pruritus, urticaria, vulvodynia

Precaution :

Tell your doctor if ...

- you are pregnant or plan to become pregnant

- younger than age 12.

- allergic to amitriptyline or similar drugs such as Norpramin and Tofranil

- have a liver or kidney disorder.

- you are taking cisapride (Propulsid) (not available in the U.S.) or monanime oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelaper), and tranylcypromine (Parnate), When used with MAO-I’s, fever, high blood pressure, increased heart rate, confusion, seizures, and deaths have been reported.

- have narrow-angle glaucoma.(an eye condition); an enlarged prostate (a male reproductive gland)

- diabetes

- have a liver or kidney disorder.

- have heart-induced chest pain (angina pectoris).

- have a rapid heart rate that occurs spontaneously (paroxysmal tachycardia).

- had a heart attack.

- have a history of schizophrenia –- as this drug may worsen any paranoia.

- have a history of prostate or sexual problems.

- have a blood cell disorder.

- have a history of intestinal block (ileus).

- difficulty urinating

- an overactive thyroid gland (hyperthyroidism)

- schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions);

Driving and Hazardous activities :

Avoid hazardous activities.

Infant and children

Not recommended for ages 12. And under.

Forget a dose :

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

Over 60 years old

More likely to develop urination difficulty and serious side effects such as insomnia,seizures, shaking,hallucinations , dizziness, fainting, headache, .

Overdose :

Irregular heartbeat , Fever,Agitation,Confusion ,Seizures,, Hallucinating (seeing things or hearing voices that do not exist),Problems concentrating, Vomiting, Rigid muscles, Drowsiness, Cold body temperature,drowsiness, enlarged pupils, respiratory failure, fever, cardiac arrhythmias, convulsions,Coma (loss of consciousness for a period of time).

Side effect and allegic reaction

More common side effects :

Tremor , Headache, dry mouth or unpleasant taste, Constipation or diarrhea, nausea, indigestion, drowsiness ,Fatigue, weakness, taste changes, nervousness,Anxiety, excessive sweating. Insomnia, “sweet tooth.”sedation and anticholinergic effects, including blurred vision, disorientation, confusion, hallucinations, muscle spasm or tremors,seizures or convulsions, constipation, especially in older adults; difficulty urinating, worsening glaucoma; and sensitivity to bright light, dizziness, drowsiness, increased appetite, irregular heartbeat, seizures, tiredness, weakness, weight gain

Less common side effects :

Convulsions , Hallucinations, shakiness, dizziness, diarrhea, fainting, Blurred vision, eye pain, abdominal pain, vomiting, urinary difficulty,  irregular Heartbeat or slow pulse, heart attack, inflamed tongue, jaundice, hair loss, rash, fever, chills, joint pain, palpitations, hiccups, visual changes,decreased sex drive, muscle aches, abnormal dreams,nasal Congestion,weakness and faintness when arising from bed or chair, back pain,blood-pressure changes, anxiety, restlessness, excitement, numbness and tingling , rash, itching, fluid retention, fever, allergy, changes in blood composition, nausea, appetite loss, upset stomach, enlargement of the breasts in men and women, and blood-sugar changes.Confusion, constipation,expressionless face, hallucinations, loss of balance, nausea, nervousness, restlessness, shakiness, shuffling walk, sleeping difficulty, stiffness, swallowing difficulty, trembling,

Rare common side effects :

Itchy skin; sore throat; involuntary movements of jaw,             lips and tongue; nightmares; confusion ,Anxiety, breast enlargement, fever, hair loss, irritability, muscle twitching, ringing in ears, skin rash, swelling, teeth or gum problems, yellow eyes or skin

Food Interaction :

Alcohol

Drug Interaction

Airway-opening drugs such as Sudafed and Proventil
Antidepressants that raise serotonin levels, such as Paxil, Prozac and Zoloft
Other antidepressants, such as Asendin
Antihistamines such as Phenobarbital
Certain blood pressure medicines such as Catapres and Ismelin
Cimetidune (Tagament)
Disulfiram (Antabuse)
Drugs that control spasms, such as Bentyl and Donnatal
Estrogen drugs such as Premarin and oral contraceptives
Ethchlorvnol (Placidyl)
Major tranquilizers such as Mellaril and Thorazine
MAO inhibitors, such as phenelzine, tranylcypromine, isocarboxazid), ritonavir, bupropion, amphetemines, anticholinergics, sedatives, chlorpropamide, tolazamide, warfarin, fluoxetine, fluvoxamine, citalopram, escitalopram, paroxetine, sertraline, cimetidine, carbamazepine
Medications for irregular heartbeat, such as Tambocor and  Rythmol
Painkillers such as Demerol and Percocet
Parkinsonism drugs such as Cogentin and Larodopa Quinidine (Quinidex)
Seizure medications such as Tegretol and Dilantin
Sleep medicines such as Halcion and Dalmane

Last update Aug 18 ,2010

 

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