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Buy Glucophage (Metformin) Online without Prescription.

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Glucophage (Metformin)

Brand name: Glucophage

Generic Name : Metformin

Manufacturer : Merck

Medicine Category : Diabetes Drug

FDA Pregnant Category :

Category B : Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women, or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was notconfirmed in controlled studies in women in the first trimester (and there is no evidence of a risk in later trimesters).

What is it used for?

Type 2 (non-insulin dependent) diabetes, when diet has failed

How does it work?

People with type 2 diabetes (non-insulin dependent diabetes) have a deficiency of a hormone called insulin. Insulin is produced by the pancreas and is the main hormone responsible for controlling sugar levels in the blood. It normally makes the cells of the body remove excess sugar from the blood. In type 2 diabetes the cells of the body are also resistant to the action of insulin that is produced, which means that blood sugar levels can become too high.

Metformin hydrochloride is a type of antidiabetic medicine known as a biguanide. It works in a number of ways to decrease the amount of sugar in the blood of people with type 2 diabetes.

Firstly, it reduces the amount of sugar produced by cells in the liver. Secondly, it increases the sensitivity of muscle cells to insulin. This enables the cells to remove sugar from the blood more effectively. Finally, it also delays absorption of sugar from the intestines into the bloodstream after eating. Overall, metformin reduces blood sugar levels both between and directly after meals.

Metformin is used as a first line treatment of type 2 diabetes, particularly in overweight people, when diet and exercise have failed to control blood sugar levels. It can also be used in combination with other antidiabetic medicines to provide better control of blood sugar.

How should Glucophage (Metformin) be used ?

Glucophage comes in tablets to take by mouth. It usually is taken two or three times a day with meals. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Glucophage exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Metformin hydrochloride extended-release tablets should be swallowed whole. Do not break, chew, or crush.

Continue to take Metformin hydrochloride even if you feel well. Do not stop taking Metformin hydrochloride without talking to your doctor.

Warning

- People taking this medicine should have regular blood tests to monitor their kidney function.
- This medicine should be discontinued prior to X-ray examinations with iodinated materials, as a temporary decrease in kidney function may occur. It should not be reinstated until kidney function has been tested and found to be normal.

- Alcohol should be avoided while you are taking this medicine, as it can increase the risk of low blood sugar (hypoglycaemia) and lactic acidosis.
- Consult your doctor about your diabetes treatment if you are due to have surgery under a general anaesthetic. In these situations blood sugar is normally controlled by insulin, so your doctor may ask you to stop taking this medicine 48 hours before surgery.

- Blood sugar levels should be monitored while taking this medicine, particularly if it is taken with other oral antidiabetic medicines or insulin.

Not to be used in

- Alcoholic intoxication
- Alcoholism
- Breastfeeding
- Cessation of breathing (respiratory failure)
- Children
- Coma due to ketoacidosis in severe and inadequately treated diabetes (diabetic coma)
- Decreased kidney function
- Decreased liver function
- Dehydration
- Heart failure
- Kidney failure
- People who have recently had a heart attack
- Reduced blood flow to vital internal organs (shock)
- Severe infections or trauma

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby.Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

This medicine should not be used during pregnancy. Control of diabetes mellitus in pregnancy is usually achieved using insulin because it provides a more stable control of blood sugar. Please consult with your doctor.
This medicine passes into breast milk. Breastfeeding mothers should therefore either stop breastfeeding while taking this medicine, or not take this medicine. Seek medical advice from your doctor.

Label warnings

Take this medication with or after food.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

-Metallic taste
- Flushing of the skin due to widening of the small blood vessels (erythema)
- Loss of appetite
- Elevated levels of lactic acid in the blood (lactic acidosis)
- Disturbances of the gut such as nausea, vomiting, diarrhoea or abdominal pain

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines ?

The following medicines can raise blood sugar levels and may therefore oppose the effect of metformin:-
- corticosteroids, such as prednisolone
- diuretics, such as bendrofluazide
- beta-2-agonists, such as salbutamol.

Cimetidine may cause an increase in the blood level of metformin. Your doctor may reduce your metformin dose if you take both medicines.

When metformin is taken with other antidiabetic medicines, such as sulphonylureas (eg gliclazide, glibenclamide) or insulin, there will be an enhanced blood sugar lowering effect. Blood sugar should be monitored.

Low blood sugar levels (hypoglycaemia) may occur, sometimes unpredictably, if metformin is taken with ACE inhibitors such as captopril.

Alcohol should be avoided while you are taking this medicine, as it can increase the risk of hypoglycaemia and lactic acidosis.

This medicine should be discontinued prior to X-ray examinations with iodinated materials, as a temporary decrease in kidney function may occur. It should not be reinstated until kidney function has been tested and found to be normal.

Recommended dosage

ADULTS

Glucophage

The usual starting dose is one 500-milligram tablet twice a day, taken with morning and evening meals. Your doctor may increase your daily dose by 500 milligrams at weekly intervals, based on your response up to a total of 2,000 milligrams.

An alternative starting dose is one 850-milligram tablet a day, taken with the morning meal. Your doctor may increase this by 850 milligrams at 14-day intervals, to a maximum of 2,550 milligrams a day.

The usual maintenance dose ranges from 1,500 to 2,550 milligrams daily. If you take more than 2,000 milligrams a day, your doctor may recommend that the medication be divided into three doses, taken with each meal.

Glucophage XR

The usual starting dose is one 500-milligram tablet once daily with the evening meal. Your doctor may increase your dose by 500 milligrams at weekly intervals, up to a maximum dosage of 2,000 milligrams a day. If a single 2,000-milligram dose fails to control your blood sugar, you may be asked to take 1,000-milligram doses twice a day. If you need more than 2,000 milligrams a day, the doctor will switch you to regular Glucophage.

CHILDREN

Glucophage

For children 10 to 16 years old, the usual starting dose is one 500-milligram tablet twice a day with meals. The dosage may be increased by 500 milligrams at weekly intervals up to a maximum of 2,000 milligrams daily. Glucophage has not been tested in children younger than 10.

Glucophage XR

This form of the drug has not been tested in children younger than 17.

OLDER ADULTS

Older people and those who are malnourished or in a weakened state are generally given lower doses of Glucophage because their kidneys may be weaker, making side effects more likely.

Overdosage

An overdose of Glucophage can cause lactic acidosis. If you suspect a Glucophage overdose, seek emergency treatment immediately.

When you miss a dose

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

Storage

Store it at room temperature.


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